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For the assessment of kidney injury severity (severity score), HE stained section images at 10 and 20 (2 at each magnification, for a total of 4 images per mouse) were graded from 0 (no damage) to 5 (most severe damage observed across the samples analyzed), based on the following parameters: (i) protein cast formation, (ii) visible tubular dilation, (iii) loss of proximal tubular cell polarization (no visible brush-border membranes) (iv) area affected (with single nephron damage to majority of the cortex with visual signs of injury)

Some medications are of concern with the ketogenic diet

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An animal model of Peyronie's like condition associated with an increase of transforming growth factor beta mRNA and protein expression

BMI body mass index WAT white adipose tissue BAT brown adipose tissue UCP1 uncoupling protein 1 NF-B nuclear factor kappa-B IL-6 interleukin-6 LPS Lipopolysaccharides CD14 cluster of differentiation 14 BAs bile acids HFD high-fat diet GM Gut Microbes PGC1 Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1- CPT1 carnitine palmitoyltransferase 1 Rb Retinoblastoma P38 MAPK P38 mitogen-activated protein kinase PPAR Peroxisome Proliferator-Activated Receptor CEBP- CCAAT Enhancer-Binding Protein IL-1 Interleukin-1 IEC intestinal epithelial cells Wnt Wingless/Integrated CEBP- CCAT/enhancer-binding protein TRAF4 TNF receptor-associated factor 4 CARM1 histone arginine methyltransferase 4 AMPK AMP-activated protein kinase ACC2 Acetyl-CoA carboxylase 2 STAT3 transcriptional activator 3 FOXO1 Forkhead box O1 GLUT4 Glucose Transporter 4 TG Triglyceride HO-1 Heme Oxygenase-1 TNF- Tumor Necrosis Factor-alpha LFD low-fat diet Glossary References 1