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Randomization of trial participants into treatment groups aims to avoid selection bias and to balance the treatment groups at baseline

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During postprandial periods there is an increase in free circulating IGF-1 via insulin-induced suppression of IGFBP-1 secretion [168170], which sequesters free IGF-1 making it unavailable

Compounds were initially tested for NNMT inhibition activity at 100 M or 1 mM concentration (compounds with no activity at 100 uM were tested at 1 mM concentration)

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