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The body interprets rapid fat loss as a significant stressor, releasing inflammatory mediators as part of the adaptive response

10.1002/cbin.10110 241 TaoY.ZhouX.LiangC.LiH.HanB.LiF.et al (2015)

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Pregnant women, breastfeeding mothers, and people with kidney, liver, or severe respiratory problems should avoid glutathione, as improper supplementation can stress metabolic pathways and increase health risks

Hyperhomocysteinemia was not correlated with uric acid levels, but it appeared to be higher in patients who had impaired renal function