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I just wanted to start by expressing our appreciation to the Committee and to the staff for the inclusion of issue number 24 regarding the addition of flavoring to medications

To a lesser extent, CYP1A1 also participates in drug metabolism, thus co-administering CYP1A1 inducers can decrease bedaquiline concentrations neglecting its effectiveness

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For instance, Tam et al

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The proposed mechanisms of action and therapeutic benefits of synthetic ATs are summarized in Table 4