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However, the underlying mechanisms are still unclear

Proteins and small RNAs can be loaded onto exosomes and delivered to target cells, interfering with various pathways

In these reactions, hydroxyl radicals act as potent oxidants, playing a role in re-establishing disrupted cellular energy dynamics

This leads to the transcription of genes involved in detoxification, antioxidation, and anti-inflammatory responses ( Figure 2 ) (90)

Arch Environ Contam Toxicol 61:135143 Mieiro CL, Pereira ME, Duarte AC, Pacheco M (2011b) Brain as a critical target of mercury in environmentally exposed fish ( Dicentrarchus labrax )bioaccumulation and oxidative stress profiles

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