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(2011) demonstrated that E2 stimulates the differentiation of fibroblasts into myofibroblasts inducing wound contraction, and increases extracellular matrix deposition and wound tensile strength (Novotn et al., 2011)

In contrast, Topoisomerase-I payloads appear more promising: labetuzumab govitecan (IMMU-130

The necessary inversion of configuration for an S N 2 process makes this reaction a stereospecific one (i.e., it affords a single stereoisomeric product that can be predicted based on the reaction mechanism)

Patients with certain medical conditions should exercise caution: those with Leber's hereditary optic neuropathy (a rare genetic condition) may experience optic nerve damage with high-dose cyanocobalamin