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Understanding the exchange of systemic HDL particles into the brain and vascular cells has diagnostic and therapeutic implications for neurodegenerative diseases

Cell death-associated DAMPs released during ferroptosis include CRT, ATP, HMGB1, and IL-33, which can promote the maturation and recruitment of antigen-presenting cells, as well as induce macrophage polarization

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Among the various polymeric materials employed in nanosystems such as polycaprolactone (PCL), chitosan, polyethylene glycol (PEG), and polyvinyl alcohol (PVA), PLGA stands out due to its unique properties

In addition to transporter blockade, imipramine exhibits antagonism at multiple receptors, including muscarinic (M1), histamine (H1), and 1-adrenergic receptors, contributing to both therapeutic and adverse effects