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The challenge lies in modulating inflammation rather than eliminating it entirely

10.1016/j.freeradbiomed.2004.04.010 54 CostaT

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31 In 1988, the discovery of single large-scale deletions of up to 7 kilobases in patients with mitochondrial myopathies 32 and a point mutation in the NADH dehydrogenase subunit 4 gene in families with LHON 33 underscored the importance of mtDNA mutations, heralding the beginning of the molecular era in mitochondrial research