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An ordered network of water molecules, which is found around the sulphonamide group, mediates hydrogen bonds between the carboxylate moiety of Asp161 and the sulphonamide and carbonyl group of inhibitor 1

doi: 10.1016/j.bbamcr.2012.01.005 47 CoppsKWhiteMJD

However, muscle blood flow, protein synthesis rates, leg strength, and muscle size did not improve

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"Dilated cardiomyopathy and neonatal lethality in mutant mice lacking manganese superoxide dismutase"