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The EPR effect for macromolecular drug delivery to solid tumors: improvement of tumor uptake, lowering of systemic toxicity, and distinct tumor imaging in vivo

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This can be observed in children with SPIGFD, who are deficient in IGF-I as well as IGFBP-3 and ALS, and in whom sc injected rhIGF-I displays a very fast serum clearance rate (118)

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[DOI] [PubMed] [Google Scholar] Woodlock TJ, Brown R, Mani M, Pompeo L, Hoffman H, Segel GB, et al