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Cardiovascular Issues: Changes in metabolic functions may increase the risk of hypertension and heart disease

Mayo and colleagues identified the GHRH receptor as a pituitary-specific G-protein-coupled receptor of the secretin/VIP (family B) class, [4] a seven-transmembrane receptor that mediates GHRH-induced cAMP accumulation and growth-hormone release, [5] and which, beyond acute GH release, drives somatotroph proliferation