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For LC-MS/MS analysis, 20 L of each plasma or urine sample was injected into a Sciex Exion LC AC system coupled with a SCIEX Triple TOF 5600 mass spectrometer (AB SCIEX, Canada)

Chronic opioid use is associated with altered gut microbiota and predicts readmissions in patients with cirrhosis

Despite promising results from preclinical studies, translation of antioxidant or antiinflammatory therapies into clinical success has been hindered by ambiguous molecular mechanisms and inconsistent safety profiles 36,37