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& Gordon, J

/ Because the final phase of detoxification requires the removal of water-soluble complexes through the kidneys, staying properly hydrated is non-negotiable

In addition, Fe 2+ has also been proved to catalyze the nitrification process of ONOO to proteins such as MnSOD, which is beneficial to oxidative stress and mitochondrial dysfunction by APAP-mediated cell death [83, 84]

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Importantly, targeting glycolytic pathways specifically in Tregs has shown potential in reversing their suppressive effects, thereby restoring effector T-cell responses and potentially enhancing the efficacy of ICIs in hyperglycemic conditions [114]

Statements Data availability statement The original contributions presented in the study are included in the article/Supplementary material, further inquiries can be directed to the corresponding author