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This notion was recently underscored by Davidson and co-authors, demonstrating that, although K-Ras-driven lung cancer cells in vitro are sensitive to glutaminase inhibition, K-Ras-driven lung tumours in vivo do not show the same dependency on glutamine and glutaminase (Davidson et al, 2016)

The uptake of peptides 26 and 27 is only slightly less compared to peptide 22 even though these peptides have a substitution of a positively charged residue (K) for Q9 or N10 as opposed to negatively charged residue (E) for Q9 in peptide 22 (Fig

According to estimates, almost 80% of cobalamin present in body is in the form of methylcobalamin

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GSTs were first recognized as enzymes inactivating xenobiotics, in particular electrophilic mutagens and carcinogens, leading to their excretion as mercapturic acids (Mannervik, 1985