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Many of these relate to tissue remodeling, antioxidant response, and anti-inflammatory pathways

4.1 Overview of autophagy Autophagy is a conserved intracellular degradation process that maintains cellular homeostasis by degrading and recycling damaged organelles and misfolded or excess proteins via autophagosomes (Yang and Klionsky, 2020)

Stack the two gaps together and the picture for the conventional protocol is unflattering: approximately one-fifteenth of the studied dose, delivered by a route that animal data suggest requires several-fold more peptide, targeting a compound whose dose-response may not be monotonic anyway