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Through structural optimization, the orally administered inhibitor DFV890 achieves colon-specific release, suppressesing ASC oligomerization and IL-1 maturation in diabetic lung injury models

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The ketogenic diet compensates for AGC1 deficiency and improves myelination

doi: 10.1016/0014-5793(72)80638-0, 78 OllingerR.KoglerP.TroppmairJ.HermannM.WurmM.DrascheA.et al

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We also provide an update on the targets and clinical prospects of different antioxidants (melatonin, N-acetylcysteine, vitamins, -lipoic acid, mineral elements, phytochemicals, nutritional antioxidants, cytoprotectants and synthetic compounds) in the treatment of CIPN with the help of preclinical and clinical studies, emphasizing the great potential of antioxidants as adjuvant strategies to mitigate CIPN