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When we consider a 20% dropout rate, at least 60 patients without missing values would be required

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Clock Gene Modulation Gene expression analysis following epitalon administration revealed alterations in: Clock gene (master circadian regulator) Cry2 gene (cryptochrome circadian component) Csnk1e gene (casein kinase involved in clock protein regulation) These gene expression changes occurred in peripheral leukocytes and lymphocytes, indicating systemic circadian regulation beyond central clock mechanisms [2]

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The exclusion of patients with COPD and asthma in key daratumumab studies and the incidence of bronchial hyperreactivity AEs seen in early trials resulted in the recommendation for post-administration prophylaxis with bronchodilators and inhaled corticosteroids in patients with a history of COPD [13, 65]

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