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So far, we have identified POS as an adaptive physiological mechanism in 83 animal species from 8 different phyla when exposed to low oxygen stress and during estivation (Moreira et al., 2016, 2017)

doi: 10.3389/fddev.2026.1692219 Received 25 August 2025 Revised 05 February 2026 Accepted 12 February 2026 Published 20 March 2026 Volume 6 - 2026 Edited by Kapila Seneviratne, University of Kelaniya, Sri Lanka Reviewed by Marina Ramal Snchez, University of Teramo, Italy Ruchika Maurya, Medical University of South Carolina, United States Raz Abdulqadir, The Pennsylvania State University (PSU), United States Updates Copyright 2026 Ryan and Brayden

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Moreover, HIF2 KO cells showed enrichment of m + 15 proline isotopologues compared to both HIF WT and HIF1 KO cells (Figure S3D)

Abstract Performance-enhancing drugs (PEDs) marketed as research compounds include unregulated peptides intended to modulate the growth hormoneinsulin-like growth factor-1 (GHIGF-1) axis

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