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In addition, in a mouse model of PD produced by injecting -syn fibrils into the animal brain, TUG469 treatment reduced pSer129 syn levels and microgliosis and astrogliosis by modulating inflammasome activation, apoptosis and autophagy [66]

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In this context, a DNA-based platform that elicit a strong protective immune response mediated by T cell response is an important strategy to rapidly adapt the COVID-19 vaccines to the new VOCs