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555 Integrating these biomarkers with computational network modeling will support the development of precision intervention strategies, such as mitophagy enhancers in conditions with PINK1-Parkin inefficiency or ER stress-modulating agents in ERAD-deficient diseases

The concentrations of CoQ 10 in the plasma of elderly people are positively correlated with levels of physical activity and cholesterol concentrations (Del Pozo-Cruz et al., 10 is associated with skeletal muscle performance during aging as evidenced by the fact that a high CoQ 10 H 2 /CoQ 10 ratio is accompanied by an increase in muscle strength (Fischer et al., 10 H 2 /CoQ 10 ratio could be predictor of sarcopenia in humans

Baek et al., 2020

The conserved residues in mammalian active site are -Cys-Val-Asn-Val-Gly-Cys-