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Contraindications of sympathomimetic amines include advanced arteriosclerosis, symptomatic cardiovascular disease, moderate to severe hypertension, hyperthyroidism, known hypersensitivity or idiosyncrasy to the sympathomimetic amines, and glaucoma

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Oral precursors (NMN/NR) are the most accessible route

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Sources and references Vitamin B12 - Health Professional Fact Sheet Vitamin B12 - Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline Vitamin B12 Supplementation Adequacy in Australian Vegan Study Participants - PMC Vitamin B12 (Cobalamin) - StatPearls - NCBI Bookshelf Inherited and acquired vitamin B12 deficiencies: Which administration route to choose for supplementation