Related studies have shown that metformin has an anti-ferroptotic effect on vascular calcification
Biochemistry 45, 96399647

18 F-FDG-PET: 18 F-fluorodexyglucose positron emission tomography GAD: Glutamate decarboxylase GADA: Gamma-aminobutyric acid GCase: Glucocerebrosidase GCH1: GTP-cyclohydrolase GDNF: Glial cell-line derived neurotrophic factor GLP1: Glucagon-like peptide-1 GSR: Global symptom relief HDRS: Hamilton Depression Rating Scale hESCs: Human embryonic stem cells HLA: Human leucocyte antigen hPSCs: Human pluripotent stem cells HSP: Heat shock protein iPSCs: Induced pluripotent stem cells LRRK2: Leukine-rich repeat kinase 2 LV: Lentivirus MADRS: Montgomery-sberg Depression Rating Scale MCI: Mild cognitive impairment MesDA: mesencephalic dopaminergic MRgFUS: Magnetic resonance imaging-guided focused ultrasound MRI: Magnetic resonance imaging NRTN: Neurturin PD: Parkinsons disease PDQ-39: Parkinsons disease questionnaire 39 PET: Positron emission tomography RA: Receptor agonist RNA: Ribonucleic acid ROC: Ras-of-complex ROS: Reactive oxygen species rTMS: Repetitive transcranial magnetic stimulation STN: Subthalamic nucleus T2DM: Type 2 diabetes mellitus TH: Tyrosine hydroxylase TMS: Transcranial magnetic stimulation UPDRS: Unified Parkinson Disease Rating Scale -synuclein : -syn References Aflaki E, Westbroek W, Sidransky E

FPN depletion in rodents drives hippocampal wasting and recall failure that replicate AD-type cognitive decay
The pre-mRNA in the constructs was engineered to splice and produce ihpRNAs with short loops
Pigment Cell Melanoma Res 36:399406 Yoneda K, Fujii M, Imaoka A, Kobayashi R, Hayashi R, Yoshida Y, Kohno T, Tsuji T (2021) Preventive effect of edaravone ointment on cyclophosphamide-chemotherapy induced alopecia