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A decrease in NAD+ adversely impacts cellular energy metabolism, while a reduction in SAM hinders the activation of genes that are vital for boosting metabolism

Thus these various types of heterogeneity may be responsible for the discrepancies in the results of COVID-19 microbiome studies published and makes it impossible to meaningfully compare on a one-to-one basis, and makes meta-analysis more difficult, as combining data across studies without considering heterogeneity may mask real signals [48,65]

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Although these models were not originally developed to study ECD, they hold significant potential for such applications

Front Immunol 15:1340702 Shakya R, Nguyen TH, Waterhouse N, Khanna R (2020) Immune contexture analysis in immuno-oncology: applications and challenges of multiplex fluorescent immunohistochemistry

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