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These agents have helped to understand the molecular and cellular levels of carcinogenesis

PLoS One 12 , e0185068 (2017)

The elevated levels of Glu in the diabetic vitreoretinal are thought to be mediated by the dysfunction of glutamate transporters on retinal Mller cells and possibly, due to the decreased expression of glutamine synthase (Li and Puro, 2002

The science supports itand so do the results

For example, a defect in mitochondrial protein import or respiratory function can amplify cytosolic stress via reactive oxygen species and altered NAD+/ATP balance