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These new findings encourage a novel working hypothesis for further research, that a chemical-modification mechanism enables transformation of HGF through interaction or reaction with LASSS under physiological conditions, resulting in the retention of HGFs biological activity after exposure to peroxynitrite, at least until an enhanced form of HGF undergoes metabolic turnover in vivo

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In brief, the subset data comprises 92 samples collected from 47 individuals, including 13 control (Ctr) and 34 MS patients, categorized by disease progression as relapsing-remitting (RR), secondary progressive (SP), or primary progressive (PP) MS (Supplementary Fig