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These sdAbs offer several advantages, including small size, high stability, remarkable specificity and affinity for the target antigen, and the ability to recognize hidden epitopes

Methods: This study investigates (i) the enzymatic functions of CD38, (ii) the in vitro effects of DARA and ISA on CD38_mediated NAD + degradation in primary MM cells and a representative MM cell line, and (iii) the in vivo dynamics of ADO and its metabolite inosine (INO) in BM and peripheral blood (PB) plasma from MM patients receiving DARA monotherapy

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Risks The NIH reports that in those with confirmed deficiency, B12 injections can have important benefits

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