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Editors note: This article was originally published Oct

Furthermore, descending inhibitory pathways, which modulate the visceral pain signal by releasing neurotransmitters such as opioids, noradrenaline, dopamine and 5-HT [94], are down-regulated in IBS patients as indicated by an increased somatic sensitivity [95]

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The following suggestions may aid in deciding the formulation of future studies in immunometabolism: Determination of the role of glutamine metabolism and exogenous supply of glutamine-derived metabolic intermediates in the essential antiviral activity of immune cells