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At the same time, limitations remain obvious: clinical data are still insufficient, most conclusions are based on experimental models, and questions of long-term safety, application protocols, and effectiveness at later stages of degeneration require additional research

In this review, we try to explain these contrary effects of vitamin E and relate this to available supplementation, the upper limits of toxicity, gender effect and finally try to come to an advice for the vitamin E supplementation under various conditions

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It is highly desirable to integrate different therapeutic methods together to achieve multimodal synergistic therapy for cancer treatment

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