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The bacterium harbors several virulence factors, such as CagA, VacA, and urease, to disrupt epithelial integrity, evade immune responses, and sustain mucosal inflammation, which can progress to atrophic gastritis, intestinal metaplasia, and ultimately gastric cancer (Sirit and Peek, 2025)

Hameed, A., Qureshi, M., Nawaz, M

Rodriguez-Crespo I, Gerber NC, Ortiz de Montellano PR

The total length of a treatment course can range from 120 mg/kg to 220 mg/kg, which can take 4 to 5 months at the typical dosage

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The small molecule GSK621 induces PERK-dependent ER stress by activating adenosine 5-monophosphate-activated protein kinase (AMPK), ultimately leading to CALR exposure on the cell surface to enhance adjuvanticity