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Although the Working Group also noted that formaldehyde has been classified by IARC as carcinogenic to humans (Group 1), no evidence was available as to whether exposure to formaldehyde at the levels arising from aspartame consumption would significantly alter normal endogenous formaldehyde concentrations.] The metabolism of aspartame and of each of its components has been studied in healthy adults and infants, lactating women, adults who are heterozygous and homozygous for phenylketonuria, and in people with diabetes, high body mass index (BMI), or non-fatty liver disease

Future studies require more validation using gene knockout models and human-derived samples

Belhasan, D

The substrate and inhibitor binding mechanism of polyspecific transporter OAT1 revealed by high-resolution cryo-EM

FTO Expression is Associated With the Occurrence of Gastric Cancer and Prognosis

However, the role of SCFAs in protein aggregation is complex (beneficial in some contexts, possibly detrimental in others as discussed) [96]