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Reinforcing previous findings 27 , our study found that L-carnitine and L-acetylcarnitine were elevated in the glaucomatous aqueous humor

doi: 10.1093/aje/kww163 38 LeonardB.MaesM

The role of Ido1 and tryptophan metabolism, together with arginine metabolizing enzymes, has been extensively studied in the context of metabolic reprogramming of immune cells for balancing immunoregulatory and pro-inflammatory phenotypes 157,158,159 , thus being critical to wound healing, neoplasia, autoimmunity and the rejection of transplanted tissues 155,160,161,162

The advantage of this type of compounds, apart from the reduction in side effects, is their efcient metabolism to non-toxic products and a high afnity for specic molecular targets, which can potentially be associated with enhanced treatment efcacy, enabling the use of a relatively low dose to produce identical biological effects [ 3 ]

pylori mediates chronic inflammation by upregulating proinflammatory cytokines, including interleukin (IL)-8, IL-1 and tumor necrosis factor (TNF) (9-11)

Even a small improvement in the efficiency of genetic vaccine vectors to enter the cells can result in a dramatic increase in the level of immune response induced by genetic vaccination