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Phase I metabolism of the alkaloids involved hydrolysis of the methyl ester of the acrylic acid group at C-16, O -demethylation of the methoxy group at C-9 and C-17 positions, followed by oxidation to carboxylic acid or reduction to alcohol (Table 1
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This, in turn, triggers their destruction, causing the white patches to form
Still, there are advantages and disadvantages to IM and SubQ
Carry a digital thermometer to check medication temperature after each transit period
