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It is involved in systemic regulation, particularly in the vascular system, where it is produced by various types of NOS

Among these, BBB penetration is the most extensively studied and is considered the most promising strategy because of its minimally invasive nature (17)

We thank the Biological Services Unit at QUB for supporting the animal studies undertaken

For instance, in human coronary artery endothelial cells, selective inhibition of PKC- by RBX during simulated ischemiareperfusion significantly restored Akt activation, enhanced anti-apoptotic signaling (iNOS, p-BAD), and suppressed pro-apoptotic mediators (p-FOXO, cleaved PARP, and caspase-3), thereby attenuating endothelial injury and supporting cardiovascular protection in both diabetic and non-diabetic settings [171]

The hippocampus, critical for memory and learning, exhibits lower methylation in active enhancers during early developmental stages (post-conceptional week 17