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Iron accumulation drives the Fenton and Haber-Weiss reactions, generating ROS that induce lipid peroxidation, leading to oxidative damage to subcellular structures (88)

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Dichloroacetate (DCA): This small molecule inhibits pyruvate dehydrogenase kinase, promoting pyruvate entry into mitochondria and favoring OXPHOS over glycolysis

Moreover, functionalized NPs can act as contrast agents in imaging techniques, selectively accumulating in affected brain areas to enhance disease detection and monitoring (126)

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Glutathione represents the most abundant intracellular antioxidant capable of (i) directly interacting with free radical species, (ii) revitalizing other small molecule antioxidants (e.g., vitamins C or E), (iii) maintaining the redox state of protein thiols, and (iv) serving as a cofactor for enzymes of the cellular antioxidant system (Espinosa-Diez et al