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Conclusion Pregabalin treatment induced significant reproductive toxicity in rats, characterized by decreased body and testicular weights, increased oxidative stress, inflammation, and apoptosis, accompanied by disruption of the hypothalamic-pituitary-gonadal axis

Glutathione is one of the major endogenous antioxidants produced by the cells , participating directly in the neutralisation of free radicals and reactive oxygen compounds

Science 242 , 715723 (1988)

& Buchner, J

The primer sequences of the target and control genes were as follows: Il6 forward: 5-ACA AAG CCA GAG TCC TTC AGA G-3 and reverse, 5-GGT CCT TAG CCA CTC CTT CTG-3

The binary Pt GSTF8 crystal structure used in molecular replacement experiments can be accessed via PDB 5F07