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Reduced expression of tyrosine hydroxylase and TPH, biochemical markers of neuronal integrity, was observed after mephedrone administration, along with downregulation of dopamine D2 receptors in the striatum, indicating the presence of damaged nerve endings 48,49

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Proc Natl Acad Sci USA 94(2):514519 Yang Y, Dieter MZ, Chen Y, Shertzer HG, Nebert DW, Dalton TP (2002) Initial characterization of the glutamate-cysteine ligase modifier subunit Gclm(/) knockout mouse

By understanding the role of the His-tag and how it binds to nickel ions on the chromatography resin, researchers can efficiently purify proteins of interest

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[DOI] [PMC free article] [PubMed] [Google Scholar] 117.Catalan E.A., Seguel-Fuentes E., Fuentes B., Aranguiz-Varela F., Castillo-Godoy D.P., Rivera-Asin E., Bocaz E., Fuentes J.A., Bravo D., Schinnerling K., et al