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Description

B.et al (2007)

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An innovative NRF2 nano-modulator induces lung cancer ferroptosis and elicits an immunostimulatory tumor microenvironment

PARP is another significant NAD+ consumer that becomes more active when DNA damage builds up

References Dixon SJ, Lemberg KM, Lamprecht MR, Skouta R, Zaitsev EM, Gleason CE, et al

(110) showed that endogenously generated NO and ROS contribute to HIF-1 accumulation by inhibiting prolyl hydroxylase domain proteins (PHDs) via S-nitrosation of PHD2, thus preventing HIF-1 degradation during hypoxia (110)