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Regulation of brain iron and copper homeostasis by brain barrier systems: implication in neurodegenerative diseases

Shaffer D, Singer S, Korvick J, Honig P

Acoustic stimuli were delivered through an open-field speaker positioned above the cage

For these six subjects, baseline GSH levels were all assigned the same value (the lowest measured GSH/Cr ratio value across all subjects and scans, divided by 2), in order to calculate the absolute change in GSH/Cr ratio relative to baseline

Arch Biochem Biophysics (1991) 288:4853

Quercetin was demonstrated to inhibit ferroptosis and improve joint cartilage destruction and degradation, delaying OA progression, by activating the AMP-activated protein kinase (AMPK)/Nrf2/GPX4 signaling pathway (Dong et al., 2025)