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158 In PASMCs and PDGF-stimulated PASMCs from PAH patients, PFKFB3 is upregulated, triggering the ERK1/2 pathway through glycolysis-generated lactate, which subsequently activates Calpain-2 and promotes cell proliferation

Although versions of these drugs have been on the market for several years, the long-term effects of taking drugs that override human metabolism are not yet clear