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In vitro and animal-model studies have examined its association with cytoskeletal organization, nitric-oxide-related signaling, angiogenesis-related mechanisms, and cellular adaptation under physiological stress

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doi: 10.3389/fphar.2021.643283 Received 17 December 2020 Accepted 04 March 2021 Published 18 May 2021 Volume 12 - 2021 Edited by Ales Tichy, University of Defence, Czechia Reviewed by Harold Swartz, Dartmouth College, United States Abdallah El-Sayed Allam, Tanta University, Egypt Klara Kubelkova, University of Defence, Czechia Updates Copyright 2021 Hollingsworth, Cassatt, DiCarlo, Rios, Satyamitra, Winters and Taliaferro

Key Insight: With no energy improvements by week 4, bloodwork can help assess whether NNMT is being effectively inhibited