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The IAP enzyme primarily stays in the lumen of the gut, such that elevated AP activity can be measured in the stool of animals that receive oral IAP supplementation

10.1161/01.cir.0000048894.99865.02 179

Macromol Res 26:955964 Banstola A, Duwa R, Emami F, Jeong J-H, Yook S (2020) enhanced caspase-mediated abrogation of autophagy by temozolomide-loaded and panitumumab-conjugated poly (lactic-co-glycolic acid) nanoparticles in epidermal growth factor receptor overexpressing glioblastoma cells

Therefore, promoting or suppressing glial reactivity should be timed appropriately to ensure optimal results depending on the stage of degeneration and regeneration