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Microglia are transformed into DAM by recognizing Neurodegeneration-Associated Molecular Pattern (NAMP) danger signals which leak from damaged neuronal cells in analogy to the peripheral immune systems pathogen- and damage-associated stress signals (PAMPs and DAMPs) 23

Excitotoxicity in neurodegenerative diseases Neurodegeneration, characterized by progressive neuronal loss, drives incurable disorders like AD, PD, HD, and amyotrophic lateral sclerosis (ALS) [60, 138]

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Following the administration of selenium supplements, there was a significant increase in the expression of selenoprotein genes (Dio3, TrxR3, Gpx1, Gpx2, Gpx4, and SelT) in the brains of conventional mice