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Consistent with their potential role as a progenitor cell, ~6% of SOX2 + AQP5 + cells coexpressed Ki67 (Figs 1E and EV1B) while 19 4% were in the cell cycle (CyclinD1 +

Although the favourable effect of tirzepatide on this endpoint appeared to be predominantly driven by a reduction in new onset macroalbuminuria [22], it is worth noting that the differences in changes in albuminuria during the time course of the study were mainly attributable to a progressive increase in the insulin glargine group whereas levels remained relatively stable in the tirzepatide-treated group

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