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3.4 Heavy metals and neurotransmitter effects in ischemic stroke Heavy metals exacerbate excitotoxicity and neuronal injury following ischemia by disrupting synaptic metal ion homeostasis and neurotransmitter systems (Figure 5)

Therefore, targeting cellular oxidative stress through antioxidants has been suggested as a potential therapeutic option against neurological disorders, particularly using natural plant extracts

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doi: 10.1073/pnas.0603339103 219 BaroneIBruscoLFuquaSAW

Mol Cell Proteomics 12:32853296