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DECLARATIONS Authors contributions Developed the model, ran simulations and analyses, interpreted the findings, and contributed to the writing and editing of the manuscript: Cruikshank A, Reed MC, Nijhout HF Availability of data and materials Computer models and codes used in this paper can be obtained from the authors by request

Oxidative stress parameters in diabetic rats submitted to forced swimming test: the clonazepam effect

Metabolomic signatures have been identified for several psychiatric disorders, such as MDD 14 , bipolar disorder 15,16 , and schizophrenia 17,18,19

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Ferroptosis Ferroptosis typically results from disruptions in iron metabolism, lipid peroxidation and decreased glutathione (GSH) levels or inactivation of GSH peroxidase 4 (GPX4) (14)