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The group receiving a 0.3 mg dose experienced a 6.0% weight loss, with 0.6 mg there was a 6.8% weight loss, with 1.2 mg there was a 9.1% weight loss, with 2.4 mg there was a 9.7% weight loss, and weigh 4.5 mg there was a 10.8% weight loss, compared with 3.0% weight loss for pooled placebo

Ethics declarations Ethics Approval and Consent to Participate This study got the permission of the Ethical Committee of Animal Experiments and Experiments Animal Welfare Capital Medical University (AEEI-2022-134)

For patients with severe depression, active suicide risk, psychosis, mania, dangerous impulsivity or potential harm to others, medication may be necessary for immediate protection and stabilization

Last, limited by the sample size and study design, the underlying interactions between genes and the environment in sporadic VCI are unclear and still need to be explored in larger longitudinal cohort studies

[3] Hair growth Copper peptide GHK-Cu and its analogues were found to stimulate hair growth

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