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Tumor heterogeneity and resistance Future studies should investigate the therapeutic potential of targeting ferroptosis resistant subpopulations in glioblastoma, which comprise 1228% of tumor cells as identified by single-cell multi-omics profiling [182]

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Therefore, the key direction for the future is to translate the above-mentioned mechanistic insights into biomarkers for patient stratification, so as to identify the specific immunometabolic states of patients (e.g., HIF-1-dominated hyperinflammatory type or Sirtuins-deficient immunosuppressive type)

Glycine betaine rather than acting only as an osmolyte also plays a role as regulator in cellular metabolism

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