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The activation of CASPASE-4 , due to promoter hypomethylation, enhanced the release of IL-1, aggravating neuroinflammation and accelerating A plaque formation (Daily et al., 2024)

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The regulatory framework anchored by FDAs 2003 BA/BE guidance and 2002 CMC guidance, and USP General Chapter defines precise measurement requirements, lifestage sampling protocols, and statistical approaches for both brand-name NDA and generic ANDA development programs

cerevisiae can be further increased by strategies of metabolic engineering and fed-batch fermentation, the highest content of ergothioneine were reported to reach 1.31 g/L [15] and 2.39 g/L [20] respectively