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The basis was the findings that DSIP modulates endogenous opioid peptidergic systems and has a significant effect on circadian rhythms and cortisol levels

10.1074/jbc.C300349200 91 HeatonR

Our work, in combination with that of others, suggests that it is the peptide metabolites of oxytocin that are responsible for the enhanced cognition, and that angiotensin IV prevents its effects by inhibiting IRAP (oxytocinase) and the metabolism of oxytocin

ml(-1)), but not on IL-6

BPC-157 doses in research typically range from 200 to 800 mcg per day, given once or twice daily by subcutaneous injection or oral capsule

Human evidence remains sparse and methodologically limited