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L., Thi, L

10.3390/nu16244360 159 ZafarS.YaddanapudiS

Systemic Inflammatory Response Shock-like Reaction A recent (2025) case report described a patient who developed full-blown systemic inflammatory response syndrome (SIRS) after a high-dose, unregulated glutathione infusion for cosmetic skin-lightening

Glutathione c th c ch kh nng sn sinh ca melanin nh qu trnh ngn chn hot ng ca cht enzyme tyrosinase

This novel approach targets LDs through autophagy, which seems reasonable and could potentially be extended to other cellular structures or biomolecules, both protein and non-protein, broadening the scope of applications for this strategy in the development of novel therapeutic interventions [84]

Importantly, most amino acid-altering mutations that reduce the overall activity of G6PD do so by decreasing protein stability, catalytic capacity or both